Relationship Between the Levels of Platelet Surface EMMPRIN, GPVI and the Stability of Coronary Plaque in Patients With Acute Coronary Syndrome / 中国循环杂志

by lfow cytometry. According to CAG morphology, the plaques included 3 types as Type I, Type II and TypeⅢ. The patients also received coronary CT angiography (CTA), upon CTA value, the plaques were classiifed by soft plaque, ifbrous plaque and calciifed plaque. Expressions of platelet surface EMMPRIN and GPVI among different groups were compared. Results:①Compared with Control group, ACS and SAP groups had increased expressions of EMMPRIN (5.82 ± 0.81 and 3.45 ± 0.48) vs (1.35 ± 0.15) and GPVI (16.22 ± 5.27 and 8.20 ± 2.87) vs (4.14 ±1.17); the expressions in ACS group were higher than those in SAP group, allP Conclusion: Expression levels of platelet surface EMMPRIN and GPVI were closely related to the stability of coronary plaque, both of them were the risk factors for severe coronary lesions. EMMPRIN and GPVI may have certain predictive value for early diagnosis of arteriosclerosis in ACS patients.

Relationship between atherosclerotic plaque characteristics and extracellular matrix metalloproteinase inducer and urokinase-type plasminogen activator in patients with coronary artery disease / 中华心血管病杂志

<p><b>OBJECTIVE</b>To explore the association between extracellular matrix metalloproteinase inducer (EMMPRIN) and urokinase-type plasminogen activator (uPA) and the severity of coronary artery lesions in coronary heart disease (CHD) patients.</p><p><b>METHODS</b>This study enrolled 88 patients with acute coronary syndrome (ACS) and 46 patients with stable angina pectoris (SAP). The mean fluorescence intensity (MFI) of EMMPRIN on monocytes of peripheral blood (PBMCs) were examined by flow cytometry. uPA in serum was measured with ELISA . 64-slice spiral computed tomography coronary artery imaging was performed in 108 CHD patients. Coronary artery plaques were divided into type I (33 patients), type II (59 patients) and type III (44 patients) through plaque morphology characteristics according to coronary angiography. Coronary artery plaques were divided into soft (42 patients), fibrous (34 patients) and calcified plaque (32 patients) according to CT characteristics.</p><p><b>RESULTS</b>(1) Type II plaque (48 patients) and soft plaque (35 patients) were the major plaque types in the ACS patients, while type Iplaque (20 patients) and type III plaque (17 patients) and fibrous plaque (16 patients) and calcified plaque (22 patients) were the major plaque types in the SAP patients. (2) The EMMPRIN expression and uPA levels were significantly higher in typeII plaque group (EMMPRIN MFI: 11.61 ± 0.81, uPA: (0.89 ± 0.17) mg/L) than those in the typeIplaque group (EMMPRIN MFI: 6.65 ± 1.32, uPA: (0.53 ± 0.06) mg/L) and in the type III plaque group (EMMPRIN MFI: 9.47 ± 1.16, uPA:(0.56 ± 0.04) mg/L, all P < 0.05). The EMMPRIN expression was higher in the typeIII plaque group (MFI: 9.47 ± 1.16) than in the typeIplaque group (MFI:6.65 ± 1.32, P < 0.05), but uPA levels were similar between the 2 groups ((0.56 ± 0.04) mg/L vs. (0.53 ± 0.06) mg/L). (3) The EMMPRIN expression and uPA levels in the soft plaque group (EMMPRIN MFI:11.37 ± 0.76, uPA: (0.97 ± 0.12)mg/L) were significantly higher than those in the fibrous plaque group (EMMPRIN MFI: 8.93 ± 1.21), uPA:(0.52 ± 0.09) mg/L) and calcified plaque group (EMMPRIN MFI: 6.94 ± 1.19, uPA:(0.49 ± 0.12) mg/L, P < 0.05). The EMMPRIN expression in the fibrous plaque group (MFI:8.93 ± 1.21) was higher than in the calcified plaque group (MFI:6.94 ± 1.19, P < 0.05), but uPA levels were similar between the two groups.</p><p><b>CONCLUSION</b>Higher EMMPRIN expression and uPA levels were associated with plaque instability, which might be used to evaluate plaque stability in CHD patients.</p>